Artur Schmidtchen Selected Research

N-(3,4,5-trichlorophenyl)succinimide

1/2021	Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments.
1/2020	Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products.
11/2018	Influence of pH on the activity of thrombin-derived antimicrobial peptides.
1/2018	Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
1/2017	Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.

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Artur Schmidtchen Research Topics

Disease

31	Infections 10/2021 - 10/2002
30	Wounds and Injuries (Trauma) 03/2021 - 10/2002
13	Inflammation (Inflammations) 03/2022 - 09/2003
10	Sepsis (Septicemia) 01/2019 - 07/2005
7	Rupture 01/2017 - 03/2007
7	Leg Ulcer 09/2012 - 01/2003
6	Bacterial Infections (Bacterial Infection) 01/2021 - 09/2010
6	Septic Shock (Toxic Shock Syndrome) 08/2020 - 07/2005
5	Surgical Wound Infection 01/2021 - 07/2011
5	Hemolysis 04/2014 - 09/2003
5	Shock 01/2014 - 04/2010
4	Atopic Dermatitis (Atopic Eczema) 08/2018 - 12/2011
3	Ulcer 10/2017 - 01/2003
2	Candidiasis (Moniliasis) 10/2021 - 08/2008
2	Wound Infection (Wound Infections) 01/2021 - 01/2020
2	Surgical Wound 01/2021 - 07/2011
2	Pseudomonas Infections 01/2016 - 01/2014
2	Hemorrhage 11/2014 - 01/2011
2	Necrosis 11/2014 - 09/2003
1	Pneumonia (Pneumonitis) 03/2022
1	COVID-19 03/2022
1	Peritonitis 10/2021
1	Autolysis 01/2021
1	Cicatrix (Scar) 03/2019
1	Coinfection 12/2018
1	Cystic Fibrosis (Mucoviscidosis) 01/2018
1	Hair Diseases 01/2018
1	Gram-Negative Bacterial Infections 01/2018
1	Adnexal Diseases 06/2016

Drug/Important Bio-Agent (IBA)

40	Peptides (Polypeptides)IBA 10/2021 - 10/2002
15	Thrombin FDA Link 10/2021 - 04/2010
8	CytokinesIBA 03/2022 - 12/2011
8	LipopolysaccharidesIBA 03/2022 - 07/2005
8	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 09/2006
8	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2003
7	EndotoxinsIBA 03/2022 - 01/2012
7	Proteins (Proteins, Gene)FDA Link 03/2022 - 01/2003
7	Liposomes (Liposome)IBA 01/2017 - 03/2007
6	Antimicrobial Cationic PeptidesIBA 01/2021 - 04/2010
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2017
5	N-(3,4,5-trichlorophenyl)succinimideIBA 01/2021 - 01/2017
5	FibrinIBA 01/2017 - 09/2003
4	Pharmaceutical PreparationsIBA 10/2021 - 10/2009
4	LipidsIBA 03/2021 - 03/2007
3	Biocompatible Materials (Biomaterials)IBA 01/2021 - 01/2015
3	tissue-factor-pathway inhibitor 2 (PP5)IBA 01/2018 - 01/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2010 - 02/2007
2	Complement System Proteins (Complement)IBA 01/2021 - 04/2014
2	Local Anti-Infective Agents (Antiseptics)IBA 01/2021 - 12/2016
2	Antimicrobial PeptidesIBA 01/2020 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 01/2020 - 01/2011
2	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2020 - 11/2018
2	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2018 - 09/2010
2	AntigensIBA 01/2018 - 01/2014
2	CollagenIBA 01/2018 - 10/2009
2	EnzymesIBA 11/2017 - 04/2010
2	EpitopesIBA 01/2017 - 01/2016
2	Arginine (L-Arginine)FDA Link 01/2016 - 11/2014
2	Heparin Cofactor IIIBA 05/2014 - 01/2014
2	CholesterolIBA 04/2011 - 06/2009
2	Phospholipids (Phosphatides)FDA LinkGeneric 04/2011 - 06/2009
2	Heme (Haem)IBA 01/2011 - 09/2003
2	histidine-rich proteinsIBA 09/2010 - 08/2008
2	Serine Proteases (Serine Protease)IBA 08/2010 - 01/2003
2	Kininogens (Kininogen)IBA 08/2009 - 01/2003
2	Pancreatic Elastase (Elastase)IBA 08/2009 - 10/2002
2	Amino Acids FDA Link 03/2007 - 07/2005
1	SARS-CoV-2 spike proteinIBA 03/2022
1	ChemokinesIBA 03/2022
1	ZymosanIBA 10/2021
1	Keratins (Keratin)IBA 03/2021
1	Polyurethanes (Polyurethane)IBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	lipoteichoic acidIBA 01/2021
1	Toll-Like Receptor AgonistsIBA 01/2021
1	Cell-Free Nucleic AcidsIBA 01/2021
1	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2020
1	HydrogelsIBA 01/2020
1	Fibrinogen (Factor I)FDA Link 01/2020
1	laponiteIBA 05/2019
1	Interleukin-8 (Interleukin 8)IBA 01/2019
1	Matrix Metalloproteinases (MMPs)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	InterleukinsIBA 08/2018
1	Carbonic Anhydrase IIIBA 08/2018
1	methacrylic acidIBA 03/2018
1	MicrogelsIBA 03/2018
1	ethyl acrylateIBA 03/2018
1	ProteomeIBA 01/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	von Willebrand FactorIBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	polihexanideIBA 12/2016
1	SolutionsIBA 12/2016
1	Interleukin-2 (IL2)IBA 06/2016

Therapy/Procedure

3	Skin Transplantation (Skin Grafting) 01/2020 - 12/2016
3	Dermatologic Surgical Procedures 03/2019 - 07/2011
2	Surgical Amputation (Amputations) 01/2019 - 01/2017
1	Mastectomy (Mammectomy) 01/2020
1	Therapeutics 01/2017